First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies

@article{Berglund2015FirstinhumanPI,
  title={First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies},
  author={Åke Berglund and Anders Ull{\'e}n and Alla Sergeevua Lisyanskaya and Sergey V. Orlov and Hans Hagberg and Bengt Tholander and Rolf Lewensohn and Peter Nygren and Jack Spira and Johan Harmenberg and Markus Jerling and Carina Alvfors and Magnus Ringbom and Eva K. L. Nordström and Karin S{\"o}derlind and Joachim Gullbo},
  journal={Investigational New Drugs},
  year={2015},
  volume={33},
  pages={1232-1241}
}
SummaryPurpose Melflufen (melphalan flufenamide, previously designated J1) is an optimized and targeted derivative of melphalan, hydrolyzed by aminopeptidases overexpressed in tumor cells resulting in selective release and trapping of melphalan, and enhanced activity in preclinical models. Methods This was a prospective, single-armed, open-label, first-in-human, dose-finding phase I/IIa study in 45 adult patients with advanced and progressive solid tumors without standard treatment options… 

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TLDR
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