First identification of circulating prepro-A-type natriuretic peptide (preproANP) signal peptide fragments in humans: initial assessment as cardiovascular biomarkers.

@article{Pemberton2012FirstIO,
  title={First identification of circulating prepro-A-type natriuretic peptide (preproANP) signal peptide fragments in humans: initial assessment as cardiovascular biomarkers.},
  author={Christopher J. Pemberton and Maithri Siriwardena and Torsten Kleffmann and Peter R. Ruygrok and Suetonia C Palmer and Tim G. Yandle and Arthur Mark Richards},
  journal={Clinical chemistry},
  year={2012},
  volume={58 4},
  pages={757-67}
}
BACKGROUND New biomarkers are needed to assist clinical decision making in cardiovascular disease. We have recently shown that signal peptides may represent a novel biomarker target in cardiovascular diseases. METHODS We developed a novel immunoassay for the signal peptide of preproANP (ANPsp) and used it to document cardiac tissue levels of ANPsp in explant human hearts (n = 9), circulating venous concentrations of ANPsp in healthy volunteers (n = 65), temporal ANPsp concentrations in… CONTINUE READING