First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump.

Abstract

Overexpression of efflux pumps is an important mechanism of bacterial resistance that results in the extrusion of antimicrobial agents outside the bacterial cell. Inhibition of such pumps appears to be a promising strategy that could restore the potency of existing antibiotics. The NorA efflux pump of Staphylococcus aureus confers resistance to a wide range… (More)
DOI: 10.1021/jm401808n

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