First identification of a chemotactic receptor in an invertebrate species: structural and functional characterization of Ciona intestinalis C3a receptor.

@article{Melillo2006FirstIO,
  title={First identification of a chemotactic receptor in an invertebrate species: structural and functional characterization of Ciona intestinalis C3a receptor.},
  author={Daniela Melillo and Georgia Sfyroera and Rosaria De Santis and Rita Graziano and Rita Marino and John D. Lambris and Maria Rosaria Pinto},
  journal={Journal of immunology},
  year={2006},
  volume={177 6},
  pages={4132-40}
}
In mammals, the bioactive fragment C3a, released from C3 during complement activation, is a potent mediator of inflammatory reactions and exerts its functional activity through the specific binding to cell surface G protein-coupled seven-transmembrane receptors. Recently, we demonstrated a Ciona intestinalis C3a (CiC3a)-mediated chemotaxis of hemocytes in the deuterostome invertebrate Ciona intestinalis and suggested an important role for this molecule in inflammatory processes. In the present… CONTINUE READING