First human Cerenkography

  title={First human Cerenkography},
  author={Antonello Enrico Spinelli and Marco Ferdeghini and Carlo Cavedon and Emanuele Zivelonghi and Riccardo Calandrino and A. Fenzi and Andrea Sbarbati and Federico Boschi},
  journal={Journal of Biomedical Optics},
Abstract. Cerenkov luminescence imaging is an emerging optical preclinical modality based on the detection of Cerenkov radiation induced by beta particles when traveling though biological tissues with a velocity greater than the speed of light. We present the first human Cerenkography obtained by detecting Cerenkov radiation escaping the thyroid gland of a patient treated for hyperthyroidism. The Cerenkov light was detected using an electron multiplied charge coupled device and a conventional C… 
Cerenkov luminescence imaging of human breast cancer: a Monte Carlo simulations study
Cerenkov luminescence imaging (CLI) is a novel molecular imaging technique based on the detection of Cerenkov light produced by beta particles traveling through biological tissues. In this paper we
Cerenkov Luminescence Imaging at a Glance
Cerenkov luminescence imaging (CLI) is a new technique that has rapidly gained great interest in the molecular imaging field bridging optical imaging and nuclear medicine. Based on the detection of
Three-Dimensional Quantitative Cerenkov Luminescence Imaging
Cerenkov luminescence imaging (CLI) is an up-and-coming optical technique for in vivo imaging of beta-emitting radioisotopes. CLI relies on measurements of the Cerenkov radiation emitted when
Computed Cerenkov luminescence yields for radionuclides used in biology and medicine.
Using Monte Carlo simulations, forty-seven different radionuclides are studied and it is shown that Cerenkov light yields in tissue can be as high as a few tens of photons per nuclear decay for a wavelength range of 400-800 nm.
A Review of Recent and Emerging Approaches for the Clinical Application of Cerenkov Luminescence Imaging
Cerenkov luminescence is a blue-weighted emission of light produced by a vast array of clinically approved radioisotopes and LINAC accelerators. When β particles (emitted during the decay of
Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging.
The fundamental breakthroughs and recent advances in reagents and instrumentation methods for CLI as well as therapeutic application of CL are covered.
Review of biomedical Čerenkov luminescence imaging applications.
This review evaluates new improvements in Čerenkov Luminescence Imaging for both medical value and biological insight.
Real-time in vivo Cherenkoscopy imaging during external beam radiation therapy
The first in vivo Cherenkov images of a real-time Cherenkoscopy during EBRT are presented and coregistration between photography and CherenKoscopy validated thatCherenkov photons were detected from the planned treatment region.
Cerenkov Luminescence Endoscopy: Improved Molecular Sensitivity with β−-Emitting Radiotracers
This work investigated the improvement in the sensitivity of CLE brought about by using a β− radiotracer that improved Cerenkov signal due to both higher β-particle energy and lower γ noise in the imaging optics because of the lack of positron annihilation.
Cerenkov imaging.
Smart imaging agents have been designed based on modulation of the Cerenkov signal using small molecules and nanoparticles giving better insight of the tumor biology, expanding the current range of applications.


Multispectral Cerenkov luminescence tomography for small animal optical imaging.
It is concluded that in vivo 3D bio-distribution of a pure beta-minus emitting radiopharmaceutical such as 32P-ATP can be obtained using the msCLT reconstruction approach.
Optimizing in vivo small animal Cerenkov luminescence imaging.
Results show that despite the smaller number of Cerenkov photons in the N IR region, the fraction exiting the tissues is greater than in the visible range, and thus, a charge-coupled device detector optimized for the NIR range will allow to obtain a higher signal.
Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers.
(18)F-FDG can be employed as it is as a bimodal tracer for positron emission tomography (PET) and OI techniques, suggesting that it could be possible to apply the proposed approach not only to beta(+) but also to pure beta(-) emitters.
Cherenkov radiation imaging of beta emitters: in vitro and in vivo results
Abstract The main purpose of this work was to investigate both in vitro and in vivo Cherenkov radiation (CR) emission coming from 18 F and 32 P. The main difference between 18 F and 32 P is mainly
In vivo 18F-FDG tumour uptake measurements in small animals using Cerenkov radiation
It is shown that CR escaping from tumour tissues of small living animals injected with 18F-FDG can be detected with optical imaging (OI) techniques using a commercial optical instrument equipped with charge-coupled detectors (CCD).
Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging.
  • A. Spinelli, M. Marengo, R. Calandrino, A. Sbarbati, F. Boschi
  • Medicine
    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...
  • 2012
An overview of the literature about the recent developments on radiotracers imaging using optical methods and their applications is presented and the use of Cerenkov radiation as the excitation source of quantum dots and fluorophores is discussed.
Optical imaging of Cerenkov light generation from positron-emitting radiotracers.
A new molecular imaging tool, Cerenkov Luminescence Imaging, the experiments conducted that support the interpretation of the source of the signal, and proof-of-concept in vivo studies that set the foundation for future application of this new method are detailed.
Molecular Optical Imaging with Radioactive Probes
These studies demonstrate generalizability of radioactive OI technique and it provides a new molecular imaging strategy and will likely have significant impact on both small animal and clinical imaging.
Combined Cerenkov luminescence and nuclear imaging of radioiodine in the thyroid gland and thyroid cancer cells expressing sodium iodide symporter: initial feasibility study.
CLI clearly demonstrated RI uptake in thyroid gland and xenografted ARO-NIS cells in mice, and a strong positive correlation was observed between CLI intensity and radioactivity assessed by NI.
in vitro and in vivo results,” Nucl
  • Instrum. Meth. A 648(Suppl. 1), S310–S312
  • 2011