First experimental evidence for the presence of a CRISPR toxin in sulfolobus.

@article{He2014FirstEE,
  title={First experimental evidence for the presence of a CRISPR toxin in sulfolobus.},
  author={Fei He and Lanming Chen and Xu Peng},
  journal={Journal of molecular biology},
  year={2014},
  volume={426 22},
  pages={3683-3688}
}
Clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated (cas) genes constitute the adaptive immune system in bacteria and archaea. Although the CRISPR-Cas systems have been hypothesized to encode potential toxins, no experimental data supporting the hypothesis are available in the literature. In this work, we provide the first experimental evidence for the presence of a toxin gene in the type I-A CRISPR system of hyperthermophilic archaeon Sulfolobus. csa5, under… CONTINUE READING
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