First evidence that bone marrow cells contribute to the construction of tissue-engineered vascular autografts in vivo.

@article{Matsumura2003FirstET,
  title={First evidence that bone marrow cells contribute to the construction of tissue-engineered vascular autografts in vivo.},
  author={Goki Matsumura and Sachiko Miyagawa-Tomita and Toshiharu Shin'oka and Yoshito Ikada and Hiromi Kurosawa},
  journal={Circulation},
  year={2003},
  volume={108 14},
  pages={1729-34}
}
BACKGROUND Materials commonly used to repair complex cardiac defects lack growth potential and have other unwanted side effects. We designed and tested a bone marrow cell (BMC)-seeded biodegradable scaffold that avoids these problems. METHODS AND RESULTS To demonstrate the contribution of the BMCs to histogenesis, we labeled them with green fluorescence, seeded them onto scaffolds, and implanted them in the inferior vena cava of dogs. The implanted grafts were analyzed immunohistochemically… CONTINUE READING

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