First evidence of the presence of adenovirus type 8 in myocardium of patients with severe idiopathic dilated cardiomyopathy

  title={First evidence of the presence of adenovirus type 8 in myocardium of patients with severe idiopathic dilated cardiomyopathy},
  author={Seyed Mohammad Javad Hosseini and Seyed Mohsen Mirhosseini and Mehdi Taghian and Mehrdad Salehi and Maryam Moshkani Farahani and Fariba Bakhtiari and Masoumeh Ghasemi-Pirbaluti and Ehsan Motaghi},
  journal={Archives of Virology},
Previous studies have detected adenovirus and cytomegalovirus (CMV) in cardiac tissue of patients with myocarditis. Therefore, in this study, we investigated the frequency of these viruses, which may be involved in the development of severe dilated cardiomyopathy (DCM). Myocardial tissue from of 23 cardiac transplant candidates with acute idiopathic DCM below the age of 40 years were analyzed by amplification of adenovirus and CMV DNA and subsequent sequencing. Adenovirus was detected in four… Expand


Cytomegalovirus infection of the heart is common in patients with fatal myocarditis.
In this population-based study, cytomegalovirus was found to be the most common specific finding in immunocompetent patients with fatal myocarditis and may have important clinical implications for the treatment of severe acuteMyocarditis. Expand
Viral causes of human myocarditis.
Using real-time PCR and reverse transcription PCR assays, parvovirus B19, Coxsackie B virus, human herpesvirus 6 (HHV-6) type B and adenovirus have been detected in 37, 33, 11 and 8% of EMB from young adults (aged<35 years) with histologically proven acute myocarditis. Expand
A myocarditis outbreak with fatal cases associated with adenovirus subgenera C among children from Havana City in 2005.
  • C. Savón, Belsy Acosta, +12 authors M. Guzmán
  • Medicine
  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2008
Adenovirus was the etiologic agent implicated in this myocarditis outbreak and adenov virus type 5 was associated with fatal outcome. Expand
Connecting the missing link between dilated cardiomyopathy and viral myocarditis: virus, cytoskeleton, and innate immunity.
An interesting situation in patients with symptoms of heart failure may show the presence of the viral genome alone, without any evidence of an overt inflammatory process, raising the question of whether the virus can be directly responsible for the cardiomyopathy or whether it is merely an incidental bystander. Expand
A fatal case of Human Herpesvirus 6 chronic myocarditis in an immunocompetent adult.
It is indicated that HHV-6 can establish a chronic active myocarditis leading to heart failure in immunocompetent subjects. Expand
Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart
The induction of expression of CAR and CD46 by endothelial cells in DCM suggests that viruses targeting these receptors could more easily gain entry to heart cells after intravascular administration, which has potential implications for the development of targeted gene therapy for heart failure. Expand
Serological and Molecular Biological Studies of Parvovirus B19, Coxsackie B Viruses, and Adenoviruses as Potential Cardiotropic Viruses in Bulgaria
The present study shows the involvement of Coxsackie B, parvovirus B19 and adenoviruses in the development of inflammatory diseases of the heart (myocarditis and pericarditis) by demonstrating the presence of specific antiviral antibodies or viral DNA in patients’ serum samples. Expand
Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy
A novel TCR transgenic mouse model permits the identification of the central pathophysiological and immunological processes involved in the transition from autoimmune myocarditis to DCM and found that IFN‐γ was a major effector cytokine driving the initial inflammatory process and that the cooperation of IFn‐γ and IL‐17A was essential for the development of the progressive disease. Expand
Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo.
It is demonstrated that eliminating CAR prevents signs of inflammatory cardiomyopathy, with essentially no pathology in KO hearts, which emphasizes the contribution of direct virus-mediated pathology in enteroviral myocarditis. Expand
Implantable cardioverter defibrillators and biventricular pacing in pediatric dilated cardiomyopathy: Preventing death and delaying heart transplant
To create evidence-based guidelines for device therapy in pediatric patients with DCM, additional studies need to be done to quantify the risks factors for SCD as well as to understand the relationship between mechanical and electrical dyssynchrony. Expand