First evidence of depressed contractility in the border zone of a human myocardial infarction.

@article{Wenk2012FirstEO,
  title={First evidence of depressed contractility in the border zone of a human myocardial infarction.},
  author={Jonathan F. Wenk and Doron Klepach and Lik Chuan Lee and Zhihong Zhang and Liang Ge and Elaine E. Tseng and Alastair D Martin and Sebastian Kozerke and Joseph H. Gorman and Robert C. Gorman and Julius M. Guccione},
  journal={The Annals of thoracic surgery},
  year={2012},
  volume={93 4},
  pages={1188-93}
}
BACKGROUND The temporal progression in extent and severity of regional myofiber contractile dysfunction in normally perfused border zone (BZ) myocardium adjacent to a myocardial infarction (MI) has been shown to be an important pathophysiologic feature of the adverse remodeling process in large animal models. We sought, for the first time, to document the presence of impaired contractility of the myofibers in the human BZ myocardium. METHODS A 62-year-old man who experienced an MI in 1985 and… CONTINUE READING
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