First evidence of a menstruating rodent: the spiny mouse (Acomys cahirinus)

@article{Bellofiore2016FirstEO,
  title={First evidence of a menstruating rodent: the spiny mouse (Acomys cahirinus)},
  author={Nadia Bellofiore and Stacey J. Ellery and Jared Mamrot and David W Walker and Peter D M Temple-Smith and Hayley Dickinson},
  journal={bioRxiv},
  year={2016}
}
A missing piece: the spiny mouse and the puzzle of menstruating species.
TLDR
It is proposed that a ≥3-fold increase in progesterone during the luteal phase of the reproductive cycle is a unique characteristic linking menstruating species and why spontaneous decidualisation, and thus menstruation, evolved in these species.
The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside
TLDR
Current knowledge of spiny mouse menstruation is summarized, with an emphasis on spiral artery formation, inflammation and endocrinology, and a new perspective on cycle variation in menstrual bleeding between individual animals is offered.
Monkeys, mice and menses: the bloody anomaly of the spiny mouse
TLDR
It is proposed that DHEA, synthesised by the spiny mouse (but not other rodents), humans and other menstruating primates, is integral in spontaneous decidualisation and therefore menstruation.
Characteristics of the endometrium in menstruating species: lessons learned from the animal kingdom†
TLDR
What is currently known about menstruating animal species with special emphasis on non-primate species: length of their menstrual cycle, ovulation, implantation, placentation, decidualization, and endometrial characteristics is summarized.
Characterization of human-like menstruation in the spiny mouse: comparative studies with the human and induced mouse model
TLDR
The first to demonstrate a primate-like pattern of natural menstruation in a rodent, with decidualization, spiral arteriole remodeling and piece-meal endometrial shedding, supports the spiny mouse as a viable model, sharing many attributes of physiological menstruation with humans.
Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases
TLDR
The use of mice as a model organism to study the mechanism of menstruation and gynaecological diseases may prove to be an important breakthrough and research findings that may aid in the treatment of menstrual disorders in women are presented.
Reproductive aging and menopause-like transition in the menstruating spiny mouse (Acomys cahirinus).
TLDR
The gradual, rather than sudden, menopausal transition suggests that the spiny mouse is a more appropriate perimenopausal model than the current rodent models in which to examine the neuroendocrine pathways that encompass all hormonal interactions in the hypothalamic-pituitary-gonadal axis.
Human Parturition: Nothing More Than a Delayed Menstruation
TLDR
It is hypothesize that many of the physiological defects that lead to complications during pregnancy and parturition are detectable already during spontaneous decidualization in the nonpregnant state and at the onset of menstruation, and can thus be determined beforeThe onset of pregnancy.
Postpartum ovulation and early pregnancy in the menstruating spiny mouse, Acomys cahirinus
TLDR
The data suggest that spiny mice may act as appropriate models of human pregnancy disorders such as implantation failure or pre-eclampsia and for a postpartum ovulation using endocrine and morphological changes observed during early pregnancy.
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References

SHOWING 1-10 OF 41 REFERENCES
Induction of Overt Menstruation in Intact Mice
TLDR
Human menstruation can be mimicked in terms of extravaginally visible bleeding, tissue remodeling, and gene regulation in naturally non-menstruating species such as intact female mice without the need for an exogenous hormone supply.
A role for menstruation in preconditioning the uterus for successful pregnancy.
Spontaneous decidual reactions and menstruation in the black mastiff bat, Molossus ater.
  • J. Rasweiler
  • Biology, Medicine
    The American journal of anatomy
  • 1991
TLDR
The ability to menstruate probably affords this bat an efficient mechanism for eliminating a highly differentiated endometrium from the usual implantation site in the event of a reproductive failure.
The oestrous cycle of the spiny mouse (Acomys cahirinus).
  • B. Peitz
  • Biology, Medicine
    Journal of reproduction and fertility
  • 1981
TLDR
The oestrous cycle of the spiny mouse (Acomys cahirinus), as determined by vaginal smears, is 11.1 +/- 1.9 (s.e.d.) days, which indicates there is an active luteal phase.
The evolution of menstruation: a new model for genetic assimilation: explaining molecular origins of maternal responses to fetal invasiveness.
TLDR
It is argued that decidualization became genetically stabilized in menstruating lineages, allowing females to prepare for pregnancy without any signal from the fetus.
Cyclic decidualization of the human endometrium in reproductive health and failure.
TLDR
The endocrine, paracrine, and autocrine cues that tightly govern this differentiation process are reviewed and how disorders that subvert the programming, initiation, or progression of decidualization compromise reproductive health and predispose for pregnancy failure is discussed.
Hormones in perinatal rat and spiny mouse: relation to altricial and precocial timing of birth.
TLDR
The observed developmental patterns of hormonal levels were found to be consistent with the observed developmental pattern of enzymic maturation in the respiratory and gastrointestinal tract, which play a critical role in the adaptation to the extrauterine environment.
Defective Soil for a Fertile Seed? Altered Endometrial Development Is Detrimental to Pregnancy Success
TLDR
It is proposed that developmental changes render the endometrium hostile to the embryo and that modifications to ART protocols should be considered to take account of the requirement for endometrial receptivity and hence increase pregnancy rates.
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