First enantioselective synthesis of isagarin , a natural product isolated from Pentas longiflora Oliv

@inproceedings{Jacobs2013FirstES,
  title={First enantioselective synthesis of isagarin , a natural product isolated from Pentas longiflora Oliv},
  author={Jan Jacobs and Sven Claessens and Eva De Mol and Samir El-Hady and Cristina Mingu{\'i}llon and Mercedes {\'A}lvarez and N. De Grande-De Kimpe},
  year={2013}
}
For the first time, an enantioselective synthesis o f both 1R,4S-isagarin 1a and 1S,4R-isagarin 1b was achieved starting from 1,4-dimethoxy-2-vinylna phtalene 2. The key steps involve a Sharpless asymmetric dihydroxylation and reaction w ith an acetonylating pyridinium ylid. ∗ To whom correspondence should be addressed. Phone : + 32 9 264 59 51. Fax: + 32 9… CONTINUE READING