First dose of potential new medicines to humans: how animals help

@article{Greaves2004FirstDO,
  title={First dose of potential new medicines to humans: how animals help},
  author={Peter Greaves and Andrew R. Williams and Malcolm D Eve},
  journal={Nature Reviews Drug Discovery},
  year={2004},
  volume={3},
  pages={226-236}
}
The need for careful testing of new drugs in animal models before study in humans has been recognised by physicians since the First World War. Now, first human studies on new drugs are subject to detailed government guidelines, which in the European Union are presently being reinforced through the wide-ranging Clinical Trials Directive. However, despite… CONTINUE READING