First-dose analgesic effect of the cyclo-oxygenase-2 selective inhibitor lumiracoxib in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled comparison with celecoxib [NCT00267215]

@article{Wittenberg2006FirstdoseAE,
  title={First-dose analgesic effect of the cyclo-oxygenase-2 selective inhibitor lumiracoxib in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled comparison with celecoxib [NCT00267215]},
  author={Ralf Hermann Wittenberg and Ernest Schell and Gerhard Krehan and Roland Maeumbaed and H. Runge and Peter Schl{\"u}ter and Taiwo OA Fashola and Helen J Thurston and Klaus J Burger and Ulrich Trechsel},
  journal={Arthritis Research & Therapy},
  year={2006},
  volume={8},
  pages={R35 - R35}
}
Cyclo-oxygenase-2 selective inhibitors are frequently used to manage osteoarthritis. We compared the analgesic efficacy of the novel cyclo-oxygenase-2 selective inhibitor lumiracoxib (Prexige) versus placebo and celecoxib in patients with knee osteoarthritis. This seven day, double-blind, placebo and active comparator controlled, parallel group study included 364 patients aged > or = 50 years with moderate-to-severe symptomatic knee osteoarthritis. Patients received lumiracoxib 400 mg/day (four… CONTINUE READING
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