First description of the t(10;11)(q22;q23)/MLL-TET1 translocation in a T-cell lymphoblastic lymphoma, with subsequent lineage switch to acute myelomonocytic myeloid leukemia.

@article{Ittel2013FirstDO,
  title={First description of the t(10;11)(q22;q23)/MLL-TET1 translocation in a T-cell lymphoblastic lymphoma, with subsequent lineage switch to acute myelomonocytic myeloid leukemia.},
  author={Antoine Ittel and Eric Jeandidier and Catherine H{\'e}lias and Nathalie Perrusson and Catherine Humbrecht and Bruno Lioure and Isabelle Mazurier and Caroline Mayeur-Rousse and Amandine Lavaux and Sylvie Thi{\'e}bault and Felix Lerintiu and Carine Gervais and Laurent Mauvieux},
  journal={Haematologica},
  year={2013},
  volume={98 12},
  pages={e166-8}
}
In the April 2013 issue of Haematologica, Lee et al. have described the TET1 genomic breakpoints and clinical features of MLL-TET1 rearranged cases of acute leukemia. So far, 13 cases have been reported in the literature, 11 in acute myeloid leukemia (AML) patients and 2 in B-cell precursor acute lymphoblastic leukemia (ALL). It was also recently reported that MLL is fused to TET1 in only 5 out of 1,590 MLL rearranged AML cases (0.3%). Although those cases are very uncommon, their study can… CONTINUE READING

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containing the t ( 10 ; 11 ) ( q 22 ; q 23 )

  • Shih L-Y, DC Liang, JF Fu, JH Wu, PN Wang, TL Lin
  • 2003

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