First cytogenetic study of a recurrent familial chordoma of the clivus.

@article{Dalpr1999FirstCS,
  title={First cytogenetic study of a recurrent familial chordoma of the clivus.},
  author={Leda Dalpr{\`a} and Roberta Malgara and Monica Miozzo and Paola Riva and M. A. Volont{\'e} and L Larizza and Anna Maria Fuhrman Conti},
  journal={International journal of cancer},
  year={1999},
  volume={81 1},
  pages={24-30}
}
Two recurrences of a familial clivus chordoma, arisen from a patient who developed the primary tumor at age of 8 years, were investigated by cytogenetic and the fluorescence in situ hybridization (FISH) approach. Of the patient's 3 daughters, 2 developed, respectively, a clivus chordoma and an astrocytoma in infancy, a familial aggregation highly suggestive of a genetic background. After a 31-year hiatus, 2 tumor recurrences, developed over 17 months, were removed surgically. Both were hypo- or… CONTINUE READING