First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial.

@article{Hagenbeek2008FirstCU,
  title={First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial.},
  author={Anton Hagenbeek and Ole V Gadeberg and Peter Johnson and Lars M\oller Pedersen and Jan Walewski and A. Hellmann and Brian K Link and Tadeusz Robak and Marek Wojtukiewicz and Michael Pfreundschuh and Michael Kneba and Andreas Engert and P. Sonneveld and Mimi Folden Flensburg and J\orgen Holm Petersen and Nedjad Losic and John Radford},
  journal={Blood},
  year={2008},
  volume={111 12},
  pages={5486-95}
}
Ofatumumab is a unique monoclonal antibody that targets a distinct small loop epitope on the CD20 molecule. Preclinical data show that ofatumumab is active against B-cell lymphoma/chronic lymphocytic leukemia cells with low CD20-antigen density and high expression of complement inhibitory molecules. In a phase 1/2 trial evaluating safety and efficacy of ofatumumab in relapsed or refractory follicular non-Hodgkin lymphoma (FL) grade 1 or 2, 4 dose groups of 10 patients received 4 weekly… CONTINUE READING
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