First clinical evidence that imaging with somatostatin receptor antagonists is feasible.

@article{Wild2011FirstCE,
  title={First clinical evidence that imaging with somatostatin receptor antagonists is feasible.},
  author={Damian Wild and M. El Fani and Martin B{\'e}h{\'e} and Ingo Brink and Jean Edouard Frederic Rivier and Jean Claude Reubi and Helmut R. Maecke and Wolfgang Weber},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2011},
  volume={52 9},
  pages={
          1412-7
        }
}
UNLABELLED Preclinical studies have indicated that somatostatin receptor (sst)-expressing tumors demonstrate higher uptake of radiolabeled sst antagonists than of sst agonists. In this study, we evaluated whether imaging with sst antagonists was feasible in patients. METHODS Biodistribution and tumor uptake of the sst antagonist (111)In-DOTA-pNO(2)-Phe-c(DCys-Tyr-DTrp-Lys-Thr-Cys)DTyrNH(2) ((111)In-DOTA-BASS) were studied in 5 patients with metastatic thyroid carcinoma or neuroendocrine… CONTINUE READING
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