First chemical synthesis of a scorpion alpha-toxin affecting sodium channels: the Aah I toxin of Androctonus australis hector.

@article{Mbarek2004FirstCS,
  title={First chemical synthesis of a scorpion alpha-toxin affecting sodium channels: the Aah I toxin of Androctonus australis hector.},
  author={Sarrah Ben M'barek and Ziad Fajloun and Sandrine Cest{\`e}le and Christiane Devaux and P Mansuelle and Amor Mosbah and Besma Jouirou and Massimo Mantegazza and Jurphaas van Rietschoten and Mohamed El Ayeb and Herv{\'e} Rochat and Jean-Marc Sabatier and François Sampieri},
  journal={Journal of peptide science : an official publication of the European Peptide Society},
  year={2004},
  volume={10 11},
  pages={666-77}
}
Aah I is a 63-residue alpha-toxin isolated from the venom of the Buthidae scorpion Androctonus australis hector, which is considered to be the most dangerous species. We report here the first chemical synthesis of Aah I by the solid-phase method, using a Fmoc strategy. The synthetic toxin I (sAah I) was renatured in DMSO-Tris buffer, purified and subjected… CONTINUE READING