First birth from a deceased donor uterus in the United States: from severe graft rejection to successful cesarean delivery.

@article{Flyckt2020FirstBF,
  title={First birth from a deceased donor uterus in the United States: from severe graft rejection to successful cesarean delivery.},
  author={Rebecca L. Flyckt and Tommaso Falcone and Cristiano Quintini and Uma C Perni and Bijan Eghtesad and Elliott G. Richards and Ruth M. Farrell and Koji Hashimoto and Charles Miller and Stephanie Ricci and Cecile A. Ferrando and Giuseppe D'Amico and Shana Maikhor and Debra Priebe and Andres G Chiesa-Vottero and Amy Heerema-McKenney and Steve Charles Mawhorter and Myra K. Feldman and Andreas G. Tzakis},
  journal={American journal of obstetrics and gynecology},
  year={2020}
}
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In this prospective study, uterus transplantation resulted in a third-trimester live birth in all cases in which pregnancies reached 20 weeks of gestation and was manageable by applying principles of generally accepted obstetric practice.
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Uterus transplantation (UTx) can provide a route to motherhood for women with Mayer–Rokitansky–Küster–Hauser syndrome (MRKHS), a congenital disorder characterized by uterovaginal aplasia, but with
The Value of a Nulliparous Uterus
U transplantation (UTx), with <100 transplants performed worldwide, is a fertility treatment that has the potential to help thousands of women affected by absolute uterine-factor infertility
Uterus transplantation for fertility preservation in patients with gynecologic cancer
TLDR
This review summarizes the animal research thus far published on uterus transplantation, the suggested recipient selections including former gynecologic cancer patients, the living and deceased donor uterus transplanted organ concepts with reported results, and updated fertility outcomes.
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References

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First live birth after uterus transplantation in the United States
  • G. Testa, G. McKenna, +11 authors L. Johannesson
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2018
TLDR
The first birth of a healthy child following uterus transplantation in the United States, from a recipient of a recipients of a uterus allograft procured from an altruistic living donor, is reported.
Meeting Report: First State-of-the-Art Meeting on Uterus Transplantation
TLDR
The mother of this first baby born after a uterus transplant suffered from absolute uterine infertility due to Mayer-Rokitansky-Kuester-Hauser (MRKH) syndrome and had received a living donor (unrelated) uterus transplant (LDUTx) from a 61-yearold donor in Gothenburg.
Living Donor Uterus Transplantation: A Single Center's Observations and Lessons Learned From Early Setbacks to Technical Success
  • G. Testa, E. C. Koon, +10 authors M. Olausson
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2017
TLDR
An in‐depth analysis of evaluation, surgical technique, and follow‐up of these five living donor uterus transplants in the United States, finding two recipients, at 6 and 3 mo, respectively, after transplant, have functioning grafts with regular menstrual cycles.
Uterus Transplantation: A Rapidly Expanding Field
TLDR
The acceptance of UTx as infertility treatment for women with AUFI is high, although the procedure remains in its infancy, and a recent large survey in Japan revealed that UTx had a twofold higher acceptance rate compared with gestational surrogacy.
Which Donor for Uterus Transplants: Brain-Dead Donor or Living Donor? A Systematic Review
TLDR
It is demonstrated that uterine transplantation is a major surgical innovation for the treatment of absolute uterine factor infertility and living and brain-dead donor strategies are not mutually exclusive and, in view of the current scarcity of uterine grafts and the anticipated future rise in demand, both will probably be necessary.
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