First birth from a deceased donor uterus in the United States: from severe graft rejection to successful cesarean delivery.

@article{Flyckt2020FirstBF,
  title={First birth from a deceased donor uterus in the United States: from severe graft rejection to successful cesarean delivery.},
  author={Rebecca L. Flyckt and Tommaso Falcone and Cristiano Quintini and Uma C Perni and Bijan Eghtesad and Elliott G. Richards and Ruth M. Farrell and Koji Hashimoto and Charles Miller and Stephanie Ricci and Cecile A Ferrando and Giuseppe D'Amico and Shana Maikhor and Debra Priebe and Andres G Chiesa-Vottero and Amy Heerema-McKenney and Steve Charles Mawhorter and Myra K. Feldman and Andreas G. Tzakis},
  journal={American journal of obstetrics and gynecology},
  year={2020}
}

Uterus procurement from deceased donor for transplantation

  • F. CastroD. Ejzenberg A. Vanin
  • Medicine
    Transplant international : official journal of the European Society for Organ Transplantation
  • 2021
A novel technique for uterus procurement and preparation for transplantation from a brain dead donor resulted in the first live birth worldwide using a uterus transplanted from a deceased donor, a landmark in reproductive medicine.

Live Birth Following Uterine Transplantation From a Nulliparous Deceased Donor.

It is provided a proof of concept that nulliparous uteri may present a suitable source of uterine grafts for uterus transplantation and Stenting may serve as a feasible treatment method for vaginal anastomotic stenosis.

First live birth after uterus transplantation in the Middle East

This is the first report of a healthy live birth after uterus transplantation in the MENAT region and it is hoped that this will motivate further progress and additional clinical trials in this area in the Middle East Region.

Twelve Live Births After Uterus Transplantation in the Dallas UtErus Transplant Study.

In this prospective study, uterus transplantation resulted in a third-trimester live birth in all cases in which pregnancies reached 20 weeks of gestation and was manageable by applying principles of generally accepted obstetric practice.

Uterus transplantation: state of the art in 2021

To provide a comprehensive review of uterus transplantation in 2021, including a discussion of pregnancy outcomes of all reported births to date, the donor and recipient selection process, the organ

Assisted Reproduction and Live Births in Uterus Transplantation—The Swedish View

Uterus transplantation has entered the scene as the first available treatment for women with absolute uterine factor infertility, and through ongoing clinical trials, this type of combined infertility treatment and major transplantation surgery will improve regarding outcomes, such as surgical success, rate of pregnancy/live birth per embryo transfer (ET), rate of term pregnancy, and rate of live births.

Living-Donor Uterus Transplantation: Pre-, Intra-, and Postoperative Parameters Relevant to Surgical Success, Pregnancy, and Obstetrics with Live Births

Uterus transplantation (UTx) can provide a route to motherhood for women with Mayer–Rokitansky–Küster–Hauser syndrome (MRKHS), a congenital disorder characterized by uterovaginal aplasia, but with

Uterus Transplantation: Revisiting the Question of Deceased Donors versus Living Donors for Organ Procurement

A stepwise approach to uterus transplantation is favored, one in which programs first begin with DD procurement before attempting LD procurement to maximize successful organ recovery and to minimize potential harms to a living donor.

The Value of a Nulliparous Uterus

The article by Fronek et al in Transplantation reports a live birth from a mother who had received a uterus from a nulliparous deceased donor, which provides valuable information that may change the previous praxis of not using uterine grafts from nullIParous donors in UTx and thereby may increase organ availability.

The First 5 Years of Uterus Transplant in the US: A Report From the United States Uterus Transplant Consortium.

Aggregate data from US centers demonstrate safety for the recipient, living donor, and child and may be used to counsel women with uterine-factor infertility on treatment options.
...

References

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First live birth after uterus transplantation in the United States

  • G. TestaG. McKenna L. Johannesson
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2018
The first birth of a healthy child following uterus transplantation in the United States, from a recipient of a recipients of a uterus allograft procured from an altruistic living donor, is reported.

Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility

The results establish proof-of-concept for treating uterine infertility by transplantation from a deceased donor, opening a path to healthy pregnancy for all women with uterine factor infertility, without need of living donors or live donor surgery.

Meeting Report: First State-of-the-Art Meeting on Uterus Transplantation

The mother of this first baby born after a uterus transplant suffered from absolute uterine infertility due to Mayer-Rokitansky-Kuester-Hauser (MRKH) syndrome and had received a living donor (unrelated) uterus transplant (LDUTx) from a 61-yearold donor in Gothenburg.

Living Donor Uterus Transplantation: A Single Center's Observations and Lessons Learned From Early Setbacks to Technical Success

  • G. TestaE. C. Koon M. Olausson
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2017
An in‐depth analysis of evaluation, surgical technique, and follow‐up of these five living donor uterus transplants in the United States, finding two recipients, at 6 and 3 mo, respectively, after transplant, have functioning grafts with regular menstrual cycles.

Uterus Transplantation: A Rapidly Expanding Field

The acceptance of UTx as infertility treatment for women with AUFI is high, although the procedure remains in its infancy, and a recent large survey in Japan revealed that UTx had a twofold higher acceptance rate compared with gestational surrogacy.

Which Donor for Uterus Transplants: Brain-Dead Donor or Living Donor? A Systematic Review

It is demonstrated that uterine transplantation is a major surgical innovation for the treatment of absolute uterine factor infertility and living and brain-dead donor strategies are not mutually exclusive and, in view of the current scarcity of uterine grafts and the anticipated future rise in demand, both will probably be necessary.