First asymmetric total synthesis of (-)-antofine by using an enantioselective catalytic phase transfer alkylation.

@article{Kim2003FirstAT,
  title={First asymmetric total synthesis of (-)-antofine by using an enantioselective catalytic phase transfer alkylation.},
  author={Sanghee Kim and Jaekwang Lee and Taeho Lee and Hyeung-Geun Park and Deukjoon Kim},
  journal={Organic letters},
  year={2003},
  volume={5 15},
  pages={2703-6}
}
[structure: see text] The first asymmetric total synthesis of a potential antitumor phenanthroindolizidine alkaloid, (-)-antofine, is described. An important feature of this synthesis is the creation of a stereogenic center by using enantioselective catalytic phase transfer alkylation, affording an unnatural alpha-amino acid derivative, together with a ring… CONTINUE READING