First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS)

  title={First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS)},
  author={Alexander Strashny},
  journal={International Journal of Impotence Research},
  • Alexander Strashny
  • Published 6 June 2019
  • Medicine, Psychology
  • International Journal of Impotence Research
Postorgasmic illness syndrome (POIS) is a rare condition that affects men and about which little is known. According to Waldinger and colleagues, men with POIS fulfill three or more of five preliminary diagnostic criteria regarding symptoms, time to onset, setting, duration, and spontaneous disappearance. We conducted a self-report study to assess, for the first time, the validity of these criteria. One hundred and twenty-seven men with self-reported POIS have completed the survey, making this… 
Editorial Comment on “First assessment of the validity of the only diagnostic criteria for postorgasmic illness syndrome (POIS)”
Even though the Strashny work is the largest study performed on POIS to date, its findings must still be interpreted with caution, as the reliability of these findings is hampered by sampling and nonresponse (response rate is not known) biases.
Clinical experience with post-orgasmic illness syndrome (POIS) patients—characteristics and possible treatment modality
  • Y. Reisman
  • Medicine, Psychology
    International Journal of Impotence Research
  • 2020
A series of 14 highly selected patients who were actively looking for medical help as POIS has a significant effect on patients and their partners are described, to increase knowledge about this syndrome and possible treatment modality.
Post-orgasmic Illness Syndrome: A Closer Look
This syndrome still needs more research to understand its mechanisms to obtain clearer treatment, and the clinician's awareness is needed to recognize this syndrome so that it is not misdiagnosed.
Post orgasmic illness syndrome: what do we know till now?
POIS is a rare condition that is underdiagnosed, most probably because of its unclear pathophysiology leading to a lack of treatment options, and further studies are warranted to investigate the prevalence, pathophysiological, and management of this debilitating condition.
Post-orgasmic Illness Syndrome
The common symptoms of Post-orgasmic illness syndrome include cognitive disturbance, fatigue, memory and concentration issues, and sometimes flulike symptoms such as rhinitis, nasal congestion, and myalgia.
Novel treatment for post-orgasmic illness syndrome: a case report and literature review
A case of Post-orgasmic illness syndrome (POIS) that was successfully treated with surgery after failed immunosuppressive therapy is reported, and a standard treatment strategy using these therapies has not been established.
The first Tunisian case of postorgasmic illness syndrome: A case report
Through a clinical observation, the first case diagnosed in Tunisia is illustrated and the difficulties in the etiological diagnosis and the therapeutic management of this syndrome are illustrated.


Post orgasmic illness syndrome (POIS)
  • M. Waldinger
  • Biology, Medicine
    Translational andrology and urology
  • 2016
Post orgasmic illness syndrome is a chronic disorder that manifests itself in POIS “attacks” that occur within a few minutes to a few hours after ejaculation, and disappear spontaneously after 3 to 7 days.
Postorgasm illness syndrome--a spectrum of illnesses.
It seems likely that postorgasm illness syndrome represents a spectrum of syndromes of differing etiologies, and treatment needs to be tailored to the likely cause.
Postorgasmic Illness Syndrome (POIS) in 45 Dutch caucasian males: clinical characteristics and evidence for an immunogenic pathogenesis (Part 1).
The combination of allergic and systemic flu-like reactions post-ejaculation together with a positive skin-prick test in the majority of males underscores the hypothesis of an "immunogenic" etiology of POIS, e.g., that POIS is caused by Type-1 and Type-IV allergy to the males' own semen, as soon it is triggered by ejaculation.
Negative allergy study in a case of postorgasmic illness syndrome (POIS).
Postorgasmic Illness Syndrome: Two Cases
The symptoms of a postejaculatory syndrome in two men with spontaneous ejaculations are described, which consists of severe fatigue, intense warmth, and a flulike state, with generalized myalgia.
Postorgasmic illness syndrome (POIS) in a Chinese man: no proof for IgE-mediated allergy to semen.
The purpose of the current work was to characterize the first diagnosed POIS patient in China and to study the allergic response of autologous semen in the affected patient and in three healthy males and to identify the pattern of IgE reactivity to patient's semen.
Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2).
Two males with POIS were successfully treated by hyposensitization with autologous semen, which supports an immunogenic/allergic etiology and underscores the clinical implication for immunological sexual medicine.
Post-orgasmic illness syndrome: a case report
A case of POIS with a manifestation of atopy that may be consistent with the allergy hypothesis is presented and it is shown that this syndrome may have a psychosomatic etiology.
Orgasmic migraine aura: Report of two cases
The incidence of acephalgic orgasmic migraine aura is unknown and should be considered as part of the differential of paroxysmal sex-related neurological symptoms, and clinically differentiated from fixed deficits, reversible cerebral vasoconstriction syndrome and post-orgasmic illness syndrome.