First- and second-generation perfluorocarbon emulsions

@article{Vorobev2009FirstAS,
  title={First- and second-generation perfluorocarbon emulsions},
  author={S. I. Vorob’ev},
  journal={Pharmaceutical Chemistry Journal},
  year={2009},
  volume={43},
  pages={209-218}
}
This review addresses first- and second-generation perfluorocarbon emulsions, which are used as blood substitutes when the use of donor blood is problematic. The first perfluorocarbon preparations created as synthetic blood substitutes started to be used in Japan (Green Cross Corporation). These were the first-generation preparations Fluosol-DA 20%, Fluosol-DA 35%, and the Russian formulation Perftoran. The disadvantages of first-generation perfluorocarbon preparations were that they could not… Expand

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References

SHOWING 1-10 OF 11 REFERENCES
Activation of plasma complement by perfluorocarbon artificial blood: probable mechanism of adverse pulmonary reactions in treated patients and rationale for corticosteroids prophylaxis
TLDR
It is concluded that adverse reactions to Fluosol are probably mediated by C activation and that steroid premedication may prevent them in susceptible patients. Expand
Perfluorocarbon as blood substitute in clinical applications and in war casualties.
TLDR
The results suggested that the FCBS had the capacity of carrying oxygen and expanding plasma volume and was efficient to apply as an alternative to blood transfusion during operation in treatment of traumatic and/or hemorrhagic shock even in war casualties. Expand
Survival of Mammals Breathing Organic Liquids Equilibrated with Oxygen at Atmospheric Pressure
TLDR
Investigation of organic fluid respiration may lead to development of a safe method to support the respiration of man by liquids equilibrated with gases at atmospheric pressure. Expand
Erythrocyte Substitute for Perfusion of Brain
In a simulated blood plasma ‘FX-80’, a liquid fluorocarbon with a high solubility for oxygen, maintains the electrical activity of a preparation of isolated rat brain. This is as effective as aExpand
Lysosomal Nature of Juxtaglomerular Granules
Demonstration by a combined histochemical and electron-microscopic technique of the ultrastructure of and acid phosphatase within the juxtaglomerular granules in kidneys of normal man and rat and inExpand
Perfluorocarbon Emulsions [in Russian], Department of Scientific and Technical Information, Russian Academy of Sciences, Pushchino
  • 1993
Perftoran [in Russian], Department of Scientific and Technical Information, Russian Academy
  • 1997
Vorob’ev, Author’s Abstract of Doctoral Thesis in Biological Sciences, Moscow
  • 1994
Vorob’ev, Author’s Abstract of Master’s Thesis in Biological Sciences, Moscow
  • 1990
Beloyartsev, Perfluorinated Hydrocarbons in Biology and Medicine [in Russian], Department of Scientific and Technical Information, Russian Academy of Sciences, Pushchino
  • 1980
...
1
2
...