First- and Second-Trimester Evaluation of Risk for Down Syndrome

@article{Ball2007FirstAS,
  title={First- and Second-Trimester Evaluation of Risk for Down Syndrome},
  author={Robert H. Ball and Aaron B. Caughey and Fergal Desmond Malone and David A. Nyberg and Christine H. Comstock and George R. Saade and Richard L. Berkowitz and Susan J Gross and Lorraine Dugoff and Sabrina Craigo and Ilan E Timor-Tritsch and Stephen R. Carr and Honor M. Wolfe and Danielle Emig and Mary E. D'Alton},
  journal={Obstetrics \& Gynecology},
  year={2007},
  volume={110},
  pages={10-17}
}
OBJECTIVE: To investigate the differences in costs and outcomes of Down syndrome screening using data from the First and Second Trimester Evaluation of Risk (FASTER) Trial. METHODS: Seven possible screening options for Down syndrome were compared: 1) Triple Screen—maternal serum alpha fetoprotein, estriol, and hCG; 2) Quad—maternal serum alpha fetoprotein, estriol, hCG, and Inhibin A; 3) Combined First—nuchal translucency, pregnancy-associated plasma protein A (PAPP-A), free &bgr;-hCG; 4… 
Comparing outcomes and costs between contingent and combined first-trimester screening strategies for Down's syndrome.
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The contingent strategy has similar effectiveness to the combined strategy, but has lower costs and fewer invasive procedures.
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Contingent model of screening is feasible, practical and cost effective in developing countries with comparable Detection Rate and False Positive Rate to Integrated screening model.
First-trimester maternal serum screening and the risk for fetal distress during labor.
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Low PAPP-A levels at first-trimester screening are associated independently with higher rates of emergency CS for nonreassuring fetal status during labor and lower pH.
First and second trimester serum tests with and without first trimester ultrasound tests for Down's syndrome screening.
TLDR
The accuracy of first and second trimester serum markers with and without first trimester ultrasound markers for the detection of Down's syndrome in the antenatal period is estimated and compared, as combinations of markers.
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
TLDR
To estimate and compare the accuracy of first trimester ultrasound markers alone, and in combination with firsttrimester serum tests for the detection of Down's syndrome, and the impact of maternal age on test performance in subgroup analyses is investigated.
Screening for adverse pregnancy outcome at early gestational age.
TLDR
The potential of first-trimester markers to screen for Down syndrome as well as other adverse outcomes such as fetal loss, pre-eclampsia, intrauterine growth retardation, and preterm delivery are described.
Beyond the first trimester screen: Can we predict who will choose invasive testing?
TLDR
Among patients with positive first trimester screen results, several demographic traits are predictive of invasive testing uptake, which can help providers to identify patients at increased risk of declining invasive testing and can help service providers anticipate educational needs.
First trimester serum tests for Down's syndrome screening.
TLDR
The aim of this review was to estimate and compare the accuracy of first trimester serum markers for the detection of Down's syndrome in the antenatal period, both as individual markers and as combinations of markers.
The relationship between first-trimester pregnancy-associated plasma protein-A levels and intrapartum fetal distress development.
TLDR
Low PAPP-A levels in the first trimester are associated with the risk of intrapartum fetal distress development and the likelihood of C/S for fetal distress, but this risk is not affected by labor induction.
The Utilization and Choices of Aneuploidy Screening in a Midwestern Population
TLDR
Reporting age-and screen-risks for T21, rather than classifying results as “positive” or “negative” based on a pre-determined threshold, was associated with a low uptake of further testing.
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The matching criteria were gestation (using an ultrasound crown–rump length or biparietal diameter measurement), duration of storage, and centre. Screening performance of the individual markers and
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