First- and Second-Trimester Evaluation of Risk for Down Syndrome

  title={First- and Second-Trimester Evaluation of Risk for Down Syndrome},
  author={R. Ball and A. Caughey and F. Malone and D. Nyberg and C. Comstock and G. Saade and R. Berkowitz and S. Gross and Lorraine Dugoff and S. Craigo and I. Timor-Tritsch and S. Carr and H. Wolfe and D. Emig and M. D'Alton},
  journal={Obstetrics & Gynecology},
  • R. Ball, A. Caughey, +12 authors M. D'Alton
  • Published 2007
  • Medicine
  • Obstetrics & Gynecology
  • OBJECTIVE: To investigate the differences in costs and outcomes of Down syndrome screening using data from the First and Second Trimester Evaluation of Risk (FASTER) Trial. METHODS: Seven possible screening options for Down syndrome were compared: 1) Triple Screen—maternal serum alpha fetoprotein, estriol, and hCG; 2) Quad—maternal serum alpha fetoprotein, estriol, hCG, and Inhibin A; 3) Combined First—nuchal translucency, pregnancy-associated plasma protein A (PAPP-A), free &bgr;-hCG; 4… CONTINUE READING
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