First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studies.

@article{Tantry2010FirstAO,
  title={First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studies.},
  author={Udaya S. Tantry and Kevin P. Bliden and Cheryl Wei and Robert F. Storey and Martin Armstrong and Kathleen A. Butler and Paul A Gurbel},
  journal={Circulation. Cardiovascular genetics},
  year={2010},
  volume={3 6},
  pages={556-66}
}
BACKGROUND The influence of cytochrome P450 (CYP) 2C19 genotype on platelet function in patients treated with ticagrelor versus clopidogrel is unknown. METHODS AND RESULTS CYP2C19 (*1, *2, *3, *4, *5, *6, *7, *8, *17) genotyping was performed in patients with coronary artery disease treated with ticagrelor (180-mg load, 90 mg BID) (n=92) or clopidogrel (600-mg load, 75 mg/d) (n=82). All patients received 75 to 100 mg/d aspirin. Platelet function was measured by aggregometry, VerifyNow P2Y12… CONTINUE READING

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