First analysis of the F508 deletion in cystic fibrosis patients from the GDR

Abstract

Cystic fibrosis (CF) patients (n = 157) from the GDR were analysed for the occurrence of the recently discovered 3bp deletion causing CF. About 50% of all investigated patients were homozygotes and about 30% heterozygotes for this deletion. Of the analysed CF chromosomes from these patients, 62% carry the deletion, which is in strong linkage disequilibrium with the KM19 restriction fragment length polymorphism allele 2 and the 1/2 XV2c/KM19 haplotype.

DOI: 10.1007/BF02428280

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@article{Grade1990FirstAO, title={First analysis of the F508 deletion in cystic fibrosis patients from the GDR}, author={Klaus Grade and Katrin Will and Reinhard Szibor and J{\"{u}rgen Gedschold and Ralph Br{\"{u}ckner and Ingrid Bauer and K. Giermann and Hagen Gorki and Jan Hein and U. Brell and C. Coutelle}, journal={Human Genetics}, year={1990}, volume={85}, pages={406-407} }