First Trial of CRISPR-Edited T cells in Lung Cancer.

@article{Lacey2020FirstTO,
  title={First Trial of CRISPR-Edited T cells in Lung Cancer.},
  author={Simon F. Lacey and Joseph A. Fraietta},
  journal={Trends in molecular medicine},
  year={2020}
}
The clinical application of CRISPR-Cas9 gene editing has been eagerly awaited since the first description of the technique in 2013. Lu and colleagues now describe the treatment of 12 patients with nonsmall-cell lung cancer (NSCLC) with PD-1 gene-edited bulk autologous T cells, with results supporting both the feasibility and safety of gene editing in cell therapy. 
2 Citations
Targeting Cancer with CRISPR/Cas9-Based Therapy
TLDR
Recent advancements in cancer-selective treatments based on the CRISPR/Cas9 system are described, especially focusing on strategies for targeted delivery of the CRisPR/cas9 machinery to affected cells, controlling Cas9 expression in tissues of interest and disrupting cancer-specific genes to result in selective death of malignant cells.

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TLDR
In a first-in-human phase I trial of patients with advanced lung cancer, infusions of autologous T cells edited to delete the PD-1 gene via CRISPR–Cas9 were well tolerated and did not lead to severe treatment-related adverse events.
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TLDR
This first-in-human, phase 1 clinical trial was designed to test the safety and feasibility of multiplex CRISPR-Cas9 gene editing of T cells from patients with advanced, refractory cancer and found the persistence of the T cells expressing the engineered TCR was much more durable than in three previous clinical trials during which T cells were infused.
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TLDR
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TLDR
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TLDR
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