First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90

Abstract

The involvement of Hsp90 in progression of diseases like cancer, neurological disorders and several pathogen related conditions is well established. Hsp90, therefore, has emerged as an attractive drug target for many of these diseases. Several small molecule inhibitors of Hsp90, such as geldanamycin derivatives, that display antitumor activity, have been… (More)
DOI: 10.1038/srep17015

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