First Report of cfr-Mediated Resistance to Linezolid in Human Staphylococcal Clinical Isolates Recovered in the United States

@article{Mendes2008FirstRO,
  title={First Report of cfr-Mediated Resistance to Linezolid in Human Staphylococcal Clinical Isolates Recovered in the United States},
  author={R. Mendes and L. Deshpande and M. Castanheira and J. Dipersio and M. Saubolle and R. Jones},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2008},
  volume={52},
  pages={2244 - 2246}
}
ABSTRACT Linezolid resistance has dominantly been mediated by mutations in 23S rRNA or ribosomal protein L4 genes. Recently, cfr has demonstrated the ability to produce a phenotype of resistance to not only oxazolidinones, but also other antimicrobial classes (phenicols, lincosamides, pleuromutilins, and streptogramin A). We describe the first detection of cfr-mediated linezolid resistance in Staphylococcus aureus and Staphylococcus epidermidis recovered from human infection cases monitored… Expand
First Report of Staphylococcal Clinical Isolates in Mexico with Linezolid Resistance Caused by cfr: Evidence of In Vivo cfr Mobilization
An oxazolidinone resistance mechanism (Cfr) was recently described in human isolates of staphylococci ([18][1]). Cfr causes posttranscriptional methylation of the 23S rRNA (A2503), affecting drugsExpand
Elevated Linezolid Resistance in Clinical cfr-Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3
TLDR
Novel L3 mutations, ΔSer145/His146Tyr and ΔMet169-Gly174, co-occurring with cfr in LZD-resistant Staphylococcus aureus isolates recovered from a hospital outbreak in Madrid, Spain are reported. Expand
Characterization of a cfr-positive methicillin-resistant Staphylococcus epidermidis strain of the lineage ST22 implicated in a life-threatening human infection.
TLDR
The cfr gene was identified in 3 methicillin-resistant Staphylococcus epidermidis isolates of lineage ST22 implicated in a fatal human infection and showed a multiresistance phenotype. Expand
Identification and Characterization of Linezolid-Resistant cfr-Positive Staphylococcus aureus USA300 Isolates from a New York City Medical Center
ABSTRACT The cfr gene was identified in three linezolid-resistant USA300 methicillin-resistant Staphylococcus aureus (MRSA) isolates collected over a 3-day period at a New York City medical center inExpand
Dissemination of two international linezolid-resistant Staphylococcus epidermidis clones in Greek hospitals.
TLDR
The growing number of infections caused by multidrug-resistant Staphylococcus epidermidis has necessitated the use of newantimicrobials, such as linezolid, and enhanced the emergence of lineZolid-resistant S. epidersmidis strains. Expand
CFR GENE MEDIATED LINEZOLID RESISTANCE IN STAPHYLOCOCCAL ISOLATES
TLDR
This is a first case report of cfr gene mediated linezolid resistance in India, encountered two resistant isolates from a tissue specimen culture with variable resistance to other antibiotics. Expand
Transferable Plasmid-Mediated Resistance to Linezolid Due to cfr in a Human Clinical Isolate of Enterococcus faecalis
TLDR
This is the first characterization of the potential horizontal transferability of the cfr gene from a human linezolid-resistant isolate of E. faecalis recovered from a patient in Thailand who received prolonged therapy with the antibiotic for the treatment of atypical mycobacterial disease. Expand
Linezolid-Resistant Staphylococcus aureus Strain 1128105, the First Known Clinical Isolate Possessing the cfr Multidrug Resistance Gene
TLDR
The cfr gene environment in this early clinical cfr-positive isolate has now been identified in Gram-positive and Gram-negative strains of clinical and veterinary origin and has been associated with multiple mobile elements, highlighting the versatility of this multidrug resistance gene and its potential for further dissemination. Expand
Multicity outbreak of linezolid-resistant Staphylococcus epidermidis associated with clonal spread of a cfr-containing strain.
  • H. Bonilla, M. Huband, +8 authors J. Quinn
  • Biology, Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2010
TLDR
A multicity outbreak of cfr-containing linezolid-resistant Staphylococcus epidermidis in Ohio was reported, and the clone containing cfr was identical in both hospitals. Expand
First Report of the Multidrug Resistance Gene cfr in Enterococcus faecalis of Animal Origin
  • Yang Liu, Yang Wang, +7 authors Jianzhong Shen
  • Medicine, Biology
  • Antimicrobial Agents and Chemotherapy
  • 2011
TLDR
The detection of a cfr- and IS1216-containing amplicon by inverse PCR suggests that IS 1216 may play a role in the dissemination of cfr by a recombination process. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
In Vitro Activities of Telithromycin, Linezolid, and Quinupristin-Dalfopristin against Streptococcus pneumoniae with Macrolide Resistance Due to Ribosomal Mutations
ABSTRACT To date, 86 of 7,746 macrolide-resistant Streptococcus pneumoniae isolates from 1999 to 2002 PROTEKT (Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin)Expand
Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.
TLDR
The characterization of sequential methicillin-resistant Staphylococcus aureus bloodstream isolates that developed resistance in a patient treated with a prolonged course of linezolid shows reversion to a susceptible phenotype associated with a loss of the T2500A mutation. Expand
Antimicrobial activity of tigecycline against community-acquired methicillin-resistant Staphylococcus aureus isolates recovered from North American medical centers.
TLDR
Tigecycline showed in vitro activity comparable with other highly active parenteral agents and represents an option for treating complicated infections caused by CA-MRSA. Expand
Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid
TLDR
It is discovered that linezolid resistance in a methicillin‐resistant Staphylococcus aureus hospital strain from Colombia is determined by the presence of the cfr gene whose product, Cfr methyltransferase, modifies adenosine at position 2503 in 23S rRNA in the large ribosomal subunit. Expand
Characterization of a Strain of Community-AssociatedMethicillin-Resistant Staphylococcus aureus WidelyDisseminated in the UnitedStates
TLDR
Comparative genomics between USA300-0114 and three other S. aureus lineages defined a set of USA300, USA400, and USA500-specific genes, which may facilitate the strain's pathogenesis within diverse environments. Expand
The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A Antibiotics
TLDR
The findings described in this study represent the first report of a gene conferring transferable resistance to pleuromutilins and oxazolidinones and the phenotype is named PhLOPSA for resistance to the following drug classes. Expand
Distribution of Genes Encoding Resistance to Macrolides, Lincosamides, and Streptogramins among Staphylococci
TLDR
Resistance to macrolides, lincosamides, and streptogramins was mainly due to the presence ofermA or ermC genes, which were detected in 259 strains, in particular those resistant to methicillin (78% of the strains). Expand
Distribution of Florfenicol Resistance Genes fexA and cfr among Chloramphenicol-Resistant Staphylococcus Isolates
TLDR
A total of 302 chloramphenicol-resistant Staphylococcus isolates were screened and the gene fexA, which has previously been shown to be part of the nonconjugative transposon Tn558, was identified in 10 of the 11 resistant isolates from animals. Expand
IS21-558 Insertion Sequences Are Involved in the Mobility of the Multiresistance Gene cfr
TLDR
The data obtained in this study identified the multiresistance gene cfr not only in three novel host species but also in a novel genetic context whose further analysis suggested that insertion sequences of the type IS21-558 are likely to be involved in the dissemination of cfr. Expand
Oxazolidinone antibiotics
TLDR
Linezolid shows promise as an alternative to glycopeptides and streptogramins to treat serious infections due to resistant gram-positive organisms and new agents with greater potency and new spectra of activity could arise from further modification of the oxazolidinone nucleus. Expand
...
1
2
3
...