First-Passage Time to Clear the Way for Receptor-Ligand Binding in a Crowded Environment.

@article{Newby2016FirstPassageTT,
  title={First-Passage Time to Clear the Way for Receptor-Ligand Binding in a Crowded Environment.},
  author={Jay M. Newby and Jun Allard},
  journal={Physical review letters},
  year={2016},
  volume={116 12},
  pages={
          128101
        }
}
  • Jay M. Newby, Jun Allard
  • Published 2016
  • Physics, Medicine, Biology
  • Physical review letters
  • Certain biological reactions, such as receptor-ligand binding at cell-cell interfaces and macromolecules binding to biopolymers, require many smaller molecules crowding a reaction site to be cleared. Examples include the T-cell interface, a key player in immunological information processing. Diffusion sets a limit for such cavitation to occur spontaneously, thereby defining a time scale below which active mechanisms must take over. We consider N independent diffusing particles in a closed… CONTINUE READING

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Citations

    Publications citing this paper.

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 36 REFERENCES

    The narrow escape problem for diffusion in cellular microdomains

    VIEW 1 EXCERPT

    First-passage kinetic Monte Carlo method.

    VIEW 2 EXCERPTS

    Uniform asymptotic approximation of diffusion to a small target.

    VIEW 1 EXCERPT

    A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen

    VIEW 1 EXCERPT