First-Pass Elimination Basic Concepts and Clinical Consequences

  title={First-Pass Elimination Basic Concepts and Clinical Consequences},
  author={S. Pond and T. Tozer},
  journal={Clinical Pharmacokinetics},
  • S. Pond, T. Tozer
  • Published 1984
  • Chemistry, Medicine
  • Clinical Pharmacokinetics
  • SummaryFirst-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling for measurement of drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and variable. The liver is usually assumed to be the major site of first-pass metabolism of a drug administered orally, but other potential sites are the gastrointestinal tract, blood, vascular endothelium… CONTINUE READING
    326 Citations

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