• DOI:10.2165/00003088-198409010-00001
Corpus ID: 28006040

First-Pass Elimination Basic Concepts and Clinical Consequences

@article{Pond1984FirstPassEB,
  title={First-Pass Elimination Basic Concepts and Clinical Consequences},
  author={S. Pond and T. Tozer},
  journal={Clinical Pharmacokinetics},
  year={1984},
  volume={9},
  pages={1-25}
}

S. Pond, T. Tozer

Published 1984

Chemistry, Medicine

Clinical Pharmacokinetics

SummaryFirst-pass elimination takes place when a drug is metabolised between its site of administration and the site of sampling for measurement of drug concentration. Clinically, first-pass metabolism is important when the fraction of the dose administered that escapes metabolism is small and variable. The liver is usually assumed to be the major site of first-pass metabolism of a drug administered orally, but other potential sites are the gastrointestinal tract, blood, vascular endothelium… CONTINUE READING

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