First-Line Herceptin® Monotherapy in Metastatic Breast Cancer

@article{Vogel2001FirstLineHM,
  title={First-Line Herceptin{\textregistered} Monotherapy in Metastatic Breast Cancer},
  author={Charles L. Vogel and Melody A Cobleigh and Debu Tripathy and John C. Gutheil and Lyndsay N. Harris and Louis Fehrenbacher and Dennis J Slamon and Maureen Murphy and William F. Novotny and Michael Burchmore and Steven Shak and Stanford J. Stewart},
  journal={Oncology},
  year={2001},
  volume={61},
  pages={37 - 42}
}
The pivotal phase II and III Herceptin® trials proved the efficacy and safety of second- or third-line single-agent Herceptin and first-line Herceptin in combination with chemotherapy, respectively. In the current trial, 114 patients were randomized to one of two dose groups of first-line Herceptin monotherapy: standard dose of 4 mg/ kg initial dose followed by 2 mg/kg intravenous (i.v.) weekly; or high dose of 8 mg/kg initial dose followed by 4 mg/kg i.v. weekly. The regimen was generally well… 
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