First-Line Disease-Modifying Therapies in Paediatric Multiple Sclerosis
@article{Johnston2012FirstLineDT, title={First-Line Disease-Modifying Therapies in Paediatric Multiple Sclerosis}, author={J. Johnston and Tsz-Yin So}, journal={Drugs}, year={2012}, volume={72}, pages={1195-1211} }
Paediatric multiple sclerosis (MS) is defined as the onset of MS before the age of 18 years. Immunomodulatory disease-modifying therapies (i.e. the interferons [IFNs] and glatiramer acetate) are considered first-line treatments in adult patients with MS, but they are largely understudied in the paediatric population.IFNβ is a type 1 IFN produced by fibroblasts. The therapeutic effect achieved by IFNβ in MS is believed to be the result of a variety of mechanisms, including the inhibition of T… CONTINUE READING
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