First Demonstration of the Role of TNF in the Pathogenesis of Disease
@article{Vilek2008FirstDO, title={First Demonstration of the Role of TNF in the Pathogenesis of Disease}, author={Jan T. Vil{\vc}ek}, journal={The Journal of Immunology}, year={2008}, volume={181}, pages={5 - 6} }
The notion that excessive production of cytokines, especially of TNF, can be central to the pathogenesis of numerous acute and chronic diseases is now widely accepted and documented. The first publication clearly demonstrating the causative role of TNF in pathology is featured in the current issue
16 Citations
A Neurologist's Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease
- Medicine, BiologyNeural plasticity
- 2015
The purpose of this review is to facilitate lowering communication barriers between the traditional anatomically based medical specialties through recognition of shared disease mechanisms and thus advance the prospects of a large group of patients with neurodegenerative conditions for whom at present little can be done.
Serum concentrations of apoptosis-associated molecules in septic children with leukemia, neutropenia and fever
- MedicineInternational Journal of Hematology
- 2017
Low levels of Fas-L and low percentage of apoptotic cells are observed in septic subjects, which may reflect the presence of sepsis among subjects with NF secondary to leukemia.
Blown Away: The Unexpected Role of Lymphotoxin in Lymphoid Organ Development
- Medicine, BiologyThe Journal of Immunology
- 2014
Lymph nodes (LNs), Peyer’s patches (PPs), and the spleen are command centers for the adaptive immune system, bringing together Ags and immune cells for the initiation of antipathogen offensives. The…
Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1)
- Biology, MedicineEuropean journal of immunology
- 2009
p21 is a cell‐cycle inhibitor that is also known to suppress autoimmunity. Here, we provide evidence of a novel role for p21 as an inhibitor of macrophage activation. LPS stimulation of p21‐deficient…
Fasciola hepatica Fatty Acid Binding Protein Inhibits TLR4 Activation and Suppresses the Inflammatory Cytokines Induced by Lipopolysaccharide In Vitro and In Vivo
- BiologyThe Journal of Immunology
- 2015
The potent anti-inflammatory properties of Fh12 demonstrated in this study open doors to further studies directed at exploring the potential of this molecule as a new class of drug against septic shock or other inflammatory diseases.
Extracellular granzyme K mediates endothelial activation through the cleavage of protease‐activated receptor‐1
- BiologyThe FEBS journal
- 2016
It is hypothesized that extracellular GzK induces a proinflammatory response in endothelial cells and characterization of downstream pathways implicated the mitogen‐activated protein kinase p38 pathway for intercellular adhesion molecule 1 expression, and both the p38 and theextracellular signal‐regulated protein kinases 1 and 2 pathways in cytokine production.
Biomaterial-Driven Immunomodulation: Cell Biology-Based Strategies to Mitigate Severe Inflammation and Sepsis
- BiologyFrontiers in Immunology
- 2020
This review aims to systematically describe the biological effects of nanoparticle properties—separate from additional small molecule or biologic delivery—on modulating innate immune cell responses in the context of severe inflammation and sepsis.
Unraveling the intracellular cross-talk governing the balance between TNFα mediated survival and apoptosis signaling
- BiologybioRxiv
- 2021
This study establishes that the dynamic cross-talk between the pJNK and pAKT transients directs the apoptosis phenotype via accumulated Caspase3 response, and demonstrates that the predictive model can be leveraged towards arriving at useful insights that can identify potential targeted therapeutic strategies for altering apoptotic response.
This information is current as Lipopolysaccharide In Vitro and In Vivo Inflammatory Cytokines Induced by Inhibits TLR4 Activation and Suppresses the Fatty Acid Binding Protein Fasciola hepatica
- Medicine
- 2015
Figueroa-Santiago and Ana M. EspinoIvelisse Martin, Kimberly Caban-Hernandez, Olgaryol.1401182http://www.jimmunol.org/content/early/2015/03/14/jimmunJ Immunol€ published online 16 March…
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