First Demonstration of the Role of TNF in the Pathogenesis of Disease

  title={First Demonstration of the Role of TNF in the Pathogenesis of Disease},
  author={Jan T. Vil{\vc}ek},
  journal={The Journal of Immunology},
  pages={5 - 6}
  • J. Vilček
  • Published 1 July 2008
  • Medicine
  • The Journal of Immunology
The notion that excessive production of cytokines, especially of TNF, can be central to the pathogenesis of numerous acute and chronic diseases is now widely accepted and documented. The first publication clearly demonstrating the causative role of TNF in pathology is featured in the current issue 
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    The Journal of Immunology
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Biomaterial-Driven Immunomodulation: Cell Biology-Based Strategies to Mitigate Severe Inflammation and Sepsis
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Unraveling the intracellular cross-talk governing the balance between TNFα mediated survival and apoptosis signaling
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This information is current as Lipopolysaccharide In Vitro and In Vivo Inflammatory Cytokines Induced by Inhibits TLR4 Activation and Suppresses the Fatty Acid Binding Protein Fasciola hepatica
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Suggested importance of monokines in pathophysiology of endotoxin shock and malaria
  • I. Clark
  • Biology, Medicine
    Klinische Wochenschrift
  • 2005
There are many similarities in the pathophysiology of gram-negative infections and in acute falciparum malaria, and the notion that macrophage derived mediators may be responsible, at least in part, for the pathology observed in malaria is suggested.
Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned
Analysis of all trial data as well as data from a recent trial in a large population of septic patients show that anti-TNF strategies may confer a small survival benefit, and better characterization of patients and a more multimodal approach by concomitantly targeting other mediators involved in sepsis may be helpful in enlarging the clinical benefit of anti- TNF therapy.
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Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
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Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin.
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