First Components Found for Key Kidney Filter

  title={First Components Found for Key Kidney Filter},
  author={I. Wickelgren},
  pages={225 - 226}
  • I. Wickelgren
  • Published 1999
  • Biology, Medicine
  • Science
  • Researchers have for the first time identified protein components of the filter, known as the "slit diaphragm," that prevents proteins from leaking into the urine from the capillaries of the glomeruli, the tiny globes of kidney tissue where the urine is formed. Kidney specialists are hailing the discoveries, one of which is described on page 312, because they may help them understand both normal kidney function and also provide therapeutic targets for a class of kidney diseases-those… CONTINUE READING
    17 Citations

    Topics from this paper

    Molecular composition and function of the slit diaphragm: nephrin, the molecule responsible for proteinuria
    • 18
    Identification and characterization of a glomerular-specific promoter from the human nephrin gene.
    • 72
    • PDF
    Expression of nephrin in pediatric kidney diseases.
    • 100
    • PDF
    Role of nephrin in cell junction formation in human nephrogenesis.
    • 121