First‐trimester screening for trisomy 21 combining biochemistry and ultrasound at individually optimal gestational ages. An interventional study

@article{Borrell2004FirsttrimesterSF,
  title={First‐trimester screening for trisomy 21 combining biochemistry and ultrasound at individually optimal gestational ages. An interventional study},
  author={Antoni Borrell and Elena Casals and Alberto Fortuny and Maria Teresa Pujol Farre and Anna Gonc{\'e} and Aurora S{\'a}nchez and Anna Soler and Vicenç Cararach and Joan Antoni Vanrell},
  journal={Prenatal Diagnosis},
  year={2004},
  volume={24}
}
To assess the effectiveness of the Combined Test in the prenatal detection of trisomy 21 in the general pregnant population using a new timing for the screening approach. 
Improved performance of first‐trimester combined screening for trisomy 21 with the double test taken before a gestational age of 10 weeks
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To evaluate if there is a performance difference in the combined screening for trisomy 21 between the double tests performed before and after 10 + 0 weeks of gestation, a comparison of single and double tests is performed.
First‐trimester screening for trisomy 21 in twin pregnancy: does the addition of biochemistry make an improvement?
To evaluate the effectiveness of the addition of first‐trimester biochemistry to fetal nuchal translucency (NT) measurement in the Combined Test when screening for trisomy 21 in twin pregnancies.
First‐trimester combined screening for trisomy 21 at 7–14 weeks' gestation
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To establish an algorithm for first‐trimester combined screening for trisomy 21 with biochemical testing from 7 to 14 weeks' gestation and ultrasound testing at 11–13 weeks.
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The aim is to describe the performance of first‐trimester combined risk assessment in twin pregnancies and to establish a baseline for the design of future clinical trials.
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To determine the sensitivity of first‐trimester ultrasound for diagnosing different structural anomalies in chromosomally normal pregnancies, and to establish the role of aneuploidy markers in the
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