First‐Trimester Sonographic Screening for Down Syndrome

  title={First‐Trimester Sonographic Screening for Down Syndrome},
  author={F. Malone and M. D'Alton},
  journal={Obstetrics & Gynecology},
  • F. Malone, M. D'Alton
  • Published 2003
  • Medicine
  • Obstetrics & Gynecology
  • Screening for Down syndrome is an important part of routine antenatal care. The most common screening method in the United States involves the assessment of a combination of factors: maternal age, multiple second-trimester serum markers, and second-trimester ultrasonography (as a so-called “genetic sonogram”). More recently, however, there has been significant interest in first-trimester methods of screening, including screening for first-trimester serum markers and the sonographic measurement… CONTINUE READING
    103 Citations

    Figures, Tables, and Topics from this paper

    First trimester Down syndrome screening: public health implications.
    • 25
    Additional benefits of first trimester screening.
    • 6
    Down syndrome screening in twins.
    • 31
    The Associations of Nuchal Translucency and Fetal Abnormalities; Significance and Implications
    • 8
    • Highly Influenced


    First-trimester screening for aneuploidy: research or standard of care?
    • 75
    Integrated screening for Down's syndrome based on tests performed during the first and second trimesters.
    • 441
    Evaluation of first trimester maternal serum and ultrasound screening for Down's syndrome in Eastern and Northern Finland
    • 37
    • PDF
    Screening of maternal serum for fetal Down's syndrome in the first trimester.
    • 195
    Assessment of the value of reporting partial screening results in prenatal screening for Down syndrome
    • 28
    First-trimester Down's syndrome screening by fetal nuchal translucency measurement in Taiwan.
    • 11
    • PDF