Firing rate homeostasis counteracts changes in stability of recurrent neural networks caused by synapse loss in Alzheimer’s disease

  title={Firing rate homeostasis counteracts changes in stability of recurrent neural networks caused by synapse loss in Alzheimer’s disease},
  author={Claudia Bachmann and Tom Tetzlaff and Renato C. Duarte and Abigail Morrison},
  journal={PLoS Computational Biology},
The impairment of cognitive function in Alzheimer’s disease is clearly correlated to synapse loss. However, the mechanisms underlying this correlation are only poorly understood. Here, we investigate how the loss of excitatory synapses in sparsely connected random networks of spiking excitatory and inhibitory neurons alters their dynamical characteristics. Beyond the effects on the activity statistics, we find that the loss of excitatory synapses on excitatory neurons reduces the network’s… 
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