Firing properties of Renshaw cells defined by Chrna2 are modulated by hyperpolarizing and small conductance ion currents Ih and ISK.

@article{Perry2015FiringPO,
  title={Firing properties of Renshaw cells defined by Chrna2 are modulated by hyperpolarizing and small conductance ion currents Ih and ISK.},
  author={Sharn Perry and Henrik Gezelius and Martin Larhammar and Markus M Hilscher and Boris Lamotte d'Incamps and Katarina E Le{\~a}o and Klas Kullander},
  journal={The European journal of neuroscience},
  year={2015},
  volume={41 7},
  pages={
          889-900
        }
}
Renshaw cells in the spinal cord ventral horn regulate motoneuron output through recurrent inhibition. Renshaw cells can be identified in vitro using anatomical and cellular criteria; however, their functional role in locomotion remains poorly defined because of the difficulty of functionally isolating Renshaw cells from surrounding motor circuits. Here we aimed to investigate whether the cholinergic nicotinic receptor alpha2 (Chrna2) can be used to identify Renshaw cells (RCs(α2)) in the mouse… CONTINUE READING

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