Firing pattern of fasciculations in ALS: evidence for axonal and neuronal origin.

@article{Kleine2008FiringPO,
  title={Firing pattern of fasciculations in ALS: evidence for axonal and neuronal origin.},
  author={Bert U. Kleine and Dick F. Stegeman and Helenius Jurgen Schelhaas and Machiel J. Zwarts},
  journal={Neurology},
  year={2008},
  volume={70 5},
  pages={353-9}
}
BACKGROUND In amyotrophic lateral sclerosis (ALS), the origin of fasciculations is disputed. We hypothesized that the discharge pattern of fasciculation potentials (FPs) would be different for FPs arising in the motor axon or in the spinal motor neuron. METHOD FPs were recorded by high-density surface EMG of the biceps brachii or vastus lateralis muscle for 15 minutes in 10 patients with ALS. Records were decomposed into different FP waveforms and their firing moments. Interspike interval… CONTINUE READING
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