Firing pattern of fasciculations in ALS: evidence for axonal and neuronal origin.

  title={Firing pattern of fasciculations in ALS: evidence for axonal and neuronal origin.},
  author={Bert U. Kleine and Dick F. Stegeman and Helenius Jurgen Schelhaas and Machiel J. Zwarts},
  volume={70 5},
BACKGROUND In amyotrophic lateral sclerosis (ALS), the origin of fasciculations is disputed. We hypothesized that the discharge pattern of fasciculation potentials (FPs) would be different for FPs arising in the motor axon or in the spinal motor neuron. METHOD FPs were recorded by high-density surface EMG of the biceps brachii or vastus lateralis muscle for 15 minutes in 10 patients with ALS. Records were decomposed into different FP waveforms and their firing moments. Interspike interval… CONTINUE READING
Highly Cited
This paper has 66 citations. REVIEW CITATIONS
30 Citations
54 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 30 extracted citations

66 Citations

Citations per Year
Semantic Scholar estimates that this publication has 66 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 54 references

Comparison of clinical methods for fasciculation detection in amyotrophic lateral sclerosis

  • AK Scheel, M Toepfer, M Kunkel, M Finkenstaedt, CD Reimers
  • Muscle Nerve
  • 2007

Clinical applications of high-density surface EMG: a systematic review

  • G Drost, DF Stegeman, BG van Engelen, MJ. Zwarts
  • J Electromyogr Kinesiol
  • 2006

Similar Papers

Loading similar papers…