Firing frequency modulation of substantia nigra reticulata neurons by 5-hydroxytryptamine

  title={Firing frequency modulation of substantia nigra reticulata neurons by 5-hydroxytryptamine},
  author={Jos{\'e} Luis G{\'o}ngora-Alfaro and Salvador Hern{\'a}ndez-L{\'o}pez and Jorge L. V. Flores-Hern{\'a}ndez and Elvira Galarraga},
  journal={Neuroscience Research},
Unitary extracellular recordings were made in in vitro rat brain slices to explore the effects of serotoninergic analogues on the spontaneous activity of substantia nigra reticulata (SNr) neurons. Most SNr neurons exhibited regular spontaneous firing (23.4 +/- 8.9 Hz, mean +/- S.E.M., n = 30) similar to that found in vivo. The most reproducible effect of serotonin (5-HT) was an increase in firing frequency found in 53% of the cells. The effect was concentration dependent and blocked by the 5… CONTINUE READING


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An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe to the substantia nigra in the rat

  • H. C. Fibiger, J. J. Miller
  • Neuroscience
  • 1977
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