Firing activity of locus coeruleus noradrenergic neurons increases in a rodent model of Parkinsonism

@article{TaoWang2009FiringAO,
  title={Firing activity of locus coeruleus noradrenergic neurons increases in a rodent model of Parkinsonism},
  author={王涛 TaoWang and Qiao-Jun Zhang 张巧俊 and 刘健 JianLiu and Zhong-Heng Wu 吴仲恒 and 王爽 ShuangWang},
  journal={Neuroscience Bulletin},
  year={2009},
  volume={25},
  pages={15-20}
}
To investigate the changes in the firing activity of noradrenergic neurons in the locus coeruleus (LC) in a rat model of Parkinson disease (PD). 2 and 4 weeks after unilateral lesion of the nigrostriatal pathway in the rat by local injection of 6-hydroxydopamine (6-OHDA) into the right substantia nigra pars compacta (SNc), the firing activity of noradrenergic neurons in LC was recorded by extracellular single unit recording. The firing rate of LC noradrenergic neurons increased significantly 2… CONTINUE READING

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