FireProtDB: database of manually curated protein stability data

  title={FireProtDB: database of manually curated protein stability data},
  author={J. Stourac and Juraj Dubrava and M. Musil and J. Hor{\'a}{\vc}kov{\'a} and J. Damborsk{\'y} and S. Mazurenko and D. Bednar},
  journal={Nucleic Acids Research},
  pages={D319 - D324}
Abstract The majority of naturally occurring proteins have evolved to function under mild conditions inside the living organisms. One of the critical obstacles for the use of proteins in biotechnological applications is their insufficient stability at elevated temperatures or in the presence of salts. Since experimental screening for stabilizing mutations is typically laborious and expensive, in silico predictors are often used for narrowing down the mutational landscape. The recent advances in… Expand

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