Fire Ant Venom Alkaloid, Isosolenopsin A, a Potent and Selective Inhibitor of Neuronal Nitric Oxide Synthase

@article{Yi2003FireAV,
  title={Fire Ant Venom Alkaloid, Isosolenopsin A, a Potent and Selective Inhibitor of Neuronal Nitric Oxide Synthase},
  author={G B Yi and D. Mc Clendon and Durisala Desaiah and J. Goddard and Adrian Lister and Jenni Moffitt and Robert K. Vander Meer and Richard de Shazo and Kevin Sang Lee and Robin William Rockhold},
  journal={International Journal of Toxicology},
  year={2003},
  volume={22},
  pages={81 - 86}
}
Massive, multiple fire ant, Solenopsis invicta, stings are often treated aggressively, particularly in the elderly, despite limited evidence of systemic toxicity due to the venom. Over 95% of the S. invicta venom is composed of piperidine alkaloid components, whose toxicity, if any, is unknown. To assess a possible pharmacological basis for systemic toxicity, an alkaloid-rich, protein-free methanol extract of the venom from whole ants was assayed for inhibitory activity on the following nitric… Expand
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References

SHOWING 1-10 OF 51 REFERENCES
Effects of fire ant venom alkaloids on platelet and neutrophil function.
TLDR
The results suggest that FAVA activation of platelets and neutrophils may occur in vivo as a response to stings by red fire ants. Expand
Mechanism of action of fire ant (Solenopsis) venoms. I. Lytic release of histamine from mast cells.
  • N. Lind
  • Biology, Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 1982
TLDR
Results indicate that C11 causes initial permeability changes in the plasma membrane followed by lytic release of histamine and other cell components that provides the fire ants with a defense of general applicability. Expand
Histamine release by fire ant (Solenopsis) venom.
  • G. Read, N. Lind, C. Oda
  • Biology, Medicine
  • Toxicon : official journal of the International Society on Toxinology
  • 1978
TLDR
Hexane extracts of venom and a synthetic piperidine were as effective as the venom itself in producing histamine release, indicating that the piperidines in the venom are responsible for most of the activity. Expand
Antibacterial Activity of Venom Alkaloids from the Imported Fire Ant, Solenopsis invicta Buren1
TLDR
A fourth alkaloid, trans-2-methyl-6-(cis-6-pentadecenyl)piperidine, which was available in minute quantity and was tested by disc-diffusion only, was ineffective against all organisms. Expand
Inhibition of neuronal nitric oxide synthase by N-phenacyl imidazoles.
TLDR
Spectral changes observed in the presence of compound A indicate that this inhibitor exerts its effect without interaction with heme iron, and compounds A and B, inhibit nNOS "noncompetitively" versus arginine, but "competitiveably" versus BH(4). Expand
Fire ant venoms: comparative analyses of alkaloidal components.
TLDR
The alkaloids of the red and black forms mainly contain an alkenyl group in position 6 and a trans configuration of the substituents on the piperidine ring, while those of the two indigenous species of North American fire ants contain alkyl substituent which are both cis and trans on the ring. Expand
Biosynthesis of the Solenopsins, venom alkaloids of the fire ants
Ants of the genus S o l e n o p s i s (Myrmicinae) secrete a venom consisting of a mixture of 2-methyl-6-alkylpiperidines accompanied in some cases by N-methylated, imino, or side-chain-unsaturatedExpand
Imported fire ant hypersensitivity. Studies of human reactions to fire ant venom.
TLDR
The venom as well as the whole body extract of fire ants was found useful for skin test diagnosis of sensitive individuals and there appear to be cross-reactive or shared antigens between fire ant venom, WBE, and WBE of other Hymenoptera. Expand
In Vitro and In Vivo Inhibition of Rat Brain Nitric Oxide Synthase Activity by Phencyclidine
TLDR
Results suggest that inhibition of brain NOS by PCP might be one of the mechanisms through which PCP causes neurotoxicity. Expand
Inhibition of rat cerebellar nitric oxide synthase by 7‐nitro indazole and related substituted indazoles
TLDR
The results indicate that 7‐NI is a potent and competitive inhibitor of rat brain NOS in vitro and also inhibits N OS in different brain regions and in the adrenal gland in vivo. Expand
...
1
2
3
4
5
...