Fire Ant Venom Alkaloid, Isosolenopsin A, a Potent and Selective Inhibitor of Neuronal Nitric Oxide Synthase

@article{Yi2003FireAV,
  title={Fire Ant Venom Alkaloid, Isosolenopsin A, a Potent and Selective Inhibitor of Neuronal Nitric Oxide Synthase},
  author={G B Yi and D. Mc Clendon and Durisala Desaiah and J. Goddard and Adrian Lister and Jenni Moffitt and Robert K Vander Meer and Richard de Shazo and K. S. Lee and Robin William Rockhold},
  journal={International Journal of Toxicology},
  year={2003},
  volume={22},
  pages={81 - 86}
}
Massive, multiple fire ant, Solenopsis invicta, stings are often treated aggressively, particularly in the elderly, despite limited evidence of systemic toxicity due to the venom. Over 95% of the S. invicta venom is composed of piperidine alkaloid components, whose toxicity, if any, is unknown. To assess a possible pharmacological basis for systemic toxicity, an alkaloid-rich, protein-free methanol extract of the venom from whole ants was assayed for inhibitory activity on the following nitric… 

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