Fipronil recognition by the FA1 site of human serum albumin

  title={Fipronil recognition by the FA1 site of human serum albumin},
  author={Paolo Ascenzi and Loris Leboffe and Daniele Toti and Fabio Polticelli and Viviana Trezza},
  journal={Journal of Molecular Recognition},
Fipronil is a broad‐spectrum pesticide widely used in agriculture, horticulture, and forestry. Because fipronil can cause a variety of toxic effects in animals and humans, its use is authorized as a pesticide in veterinary medicinal products for pets, but not for the treatment of livestock animals whose products are intended for consumption. Recently, however, the presence of fipronil residues has been detected in the eggs and meat of layer hens from farms located in different European… 
6 Citations
Neonicotinoid trapping by the FA1 site of human serum albumin
Values of Kn here determined suggest that the formation of the HSA:neonicotinoid complexes may occur in vivo, and HSA appears to be an important determinant for neonicotinoids transport and distribution to tissues and organs, particularly to the liver where they are metabolized.
Preclinical Transplacental Transfer and Pharmacokinetics of Fipronil in Rats
This research provided evidence on the pharmacokinetics and transplacental transfer of fipronil and fipronsil sulfone, confirming the hypothesis that they would enter fetuses through the blood-placenta barrier.
Binding of direct oral anticoagulants to the FA1 site of human serum albumin
Values of KDOAC here determined indicate that the formation of the HSA:DOACs complexes in the absence and presence of FAs and heme‐Fe(III) may occur in vivo, and HSA appears to be an important determinant for DOACs transport.
Human Exposure of Fipronil Insecticide and the Associated Health Risk.
This Perspective highlights the lack of epidemiological studies and total diet studies for the general population on fipronil, as well as results of human biomonitoring studies, which will contribute to future assessment of fipronsil exposure and subsequent characterization of human health risks.


Cantharidin inhibits competitively heme‐Fe(III) binding to the FA1 site of human serum albumin
The competitive inhibitory effect of cantharidin on heme‐Fe(III) binding to the fatty acid site 1 (FA1) of human serum albumin (HSA) is reported and may be relevant in vivo as HSA could transport canthoridin, which in turn could affect heme-Fe( III) scavenging by HSA.
Fipronil insecticide toxicology: oxidative stress and metabolism
The present review reports that studies have been conducted to reveal the generation of reactive oxygen species (ROS) and oxidative stress as a result of FIP treatment and have correlated them with various types of toxicity.
Fipronil: environmental fate, ecotoxicology, and human health concerns.
The indications are that fipronil may be incompatible with locust IPM; hence, this possibility requires further urgent investigation, and great care should be taken in using these formulations where they may impact any of these endangered wildlife groups.
Further characterization of specific drug binding sites on human serum albumin.
The specificity of the sites for particular drugs, even at high drug to albumin ratios, was established, and the specificity and characteristics of the two sites on human adult and neonatal sera were shown to be similar to those on crystalline HSA.
α-Tocopherol binding to human serum albumin.
Competitive and allosteric modulation of α-tocopherol binding to full-length and truncated HSA by endogenous and exogenous ligands suggests that it accommodates preferentially in the FA3-FA4 site.
Large-scale production of functional human serum albumin from transgenic rice seeds
The production of Oryza sativa recombinant HSA (OsrHSA) from transgenic rice seeds is reported, which displays similar in vitro and in vivo immunogenicity as pHSA and can help to satisfy an increasing worldwide demand for human serum albumin.
Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites
A review of the global literature shows a growing body of evidence that persistent, low concentrations of these insecticides pose serious risks of undesirable environmental impacts and a global evaluation of the potential collateral effects of their use is timely.
Photochemical studies on the binding of an organic fluoride to bovine serum albumin
The interaction of fipronil (FPN), a pesticide containing fluorine, to bovine serum albumin (BSA) was studied by spectroscopy and the results indicate that hydrophobic forces played major role in the reaction.
Crystal structural analysis of human serum albumin complexed with hemin and fatty acid
The structure of the HSA-hemin-myristate complex (PDB ID 1o9x) reveals the key polar and hydrophobic interactions that determine the hemin-binding specificity of HSA.