Fipronil recognition by the FA1 site of human serum albumin

@article{Ascenzi2018FipronilRB,
  title={Fipronil recognition by the FA1 site of human serum albumin},
  author={Paolo Ascenzi and Loris Leboffe and Daniele Toti and Fabio Polticelli and Viviana Trezza},
  journal={Journal of Molecular Recognition},
  year={2018},
  volume={31}
}
Fipronil is a broad‐spectrum pesticide widely used in agriculture, horticulture, and forestry. Because fipronil can cause a variety of toxic effects in animals and humans, its use is authorized as a pesticide in veterinary medicinal products for pets, but not for the treatment of livestock animals whose products are intended for consumption. Recently, however, the presence of fipronil residues has been detected in the eggs and meat of layer hens from farms located in different European… 
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6 Citations

6 Citations

Citation Type

Citation Type

Neonicotinoid trapping by the FA1 site of human serum albumin
TLDR
Values of Kn here determined suggest that the formation of the HSA:neonicotinoid complexes may occur in vivo, and HSA appears to be an important determinant for neonicotinoids transport and distribution to tissues and organs, particularly to the liver where they are metabolized.
Preclinical Transplacental Transfer and Pharmacokinetics of Fipronil in Rats
TLDR
This research provided evidence on the pharmacokinetics and transplacental transfer of fipronil and fipronsil sulfone, confirming the hypothesis that they would enter fetuses through the blood-placenta barrier.
Binding of direct oral anticoagulants to the FA1 site of human serum albumin
TLDR
Values of KDOAC here determined indicate that the formation of the HSA:DOACs complexes in the absence and presence of FAs and heme‐Fe(III) may occur in vivo, and HSA appears to be an important determinant for DOACs transport.
A fluorescent sensor recognized by the FA1 site for highly sensitive detection of HSA.
Human Exposure of Fipronil Insecticide and the Associated Health Risk.
TLDR
This Perspective highlights the lack of epidemiological studies and total diet studies for the general population on fipronil, as well as results of human biomonitoring studies, which will contribute to future assessment of fipronsil exposure and subsequent characterization of human health risks.
Highly sensitive fipronil pesticide detection on ilmenite (FeO.TiO2)-carbon paste composite electrode

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