Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage.

@article{Rolland2013FingolimodRC,
  title={Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage.},
  author={William B. Rolland and Tim Lekic and Paul R Krafft and Yu Hasegawa and Orhan Altay and Richard E Hartman and Robert P Ostrowski and Anatol Manaenko and Jiping Tang and John H Zhang},
  journal={Experimental neurology},
  year={2013},
  volume={241},
  pages={45-55}
}
T-lymphocytes promote cerebral inflammation, thus aggravating neuronal injury after stroke. Fingolimod, a sphingosine 1-phosphate receptor analog, prevents the egress of lymphocytes from primary and secondary lymphoid organs. Based on these findings, we hypothesized fingolimod treatment would reduce the number of T-lymphocytes migrating into the brain, thereby ameliorating cerebral inflammation following experimental intracerebral hemorrhage (ICH). We investigated the effects of fingolimod in… CONTINUE READING

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