Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype.

@article{Heinen2015FingolimodIT,
  title={Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype.},
  author={Andr{\'e} P Heinen and Felix Beyer and Nevena Tzekova and Hans-Peter Hartung and Patrick K{\"u}ry},
  journal={Experimental neurology},
  year={2015},
  volume={271},
  pages={25-35}
}
Successful regeneration of injured peripheral nerves is mainly attributed to the plastic behavior of Schwann cells. Upon loss of axons, these cells trans-differentiate into regeneration promoting repair cells which provide trophic support to regrowing axons. Among others, activation of cJun was revealed to be involved in this process, initiating the stereotypic pattern of Schwann cell phenotype alterations during Wallerian degeneration. Nevertheless, the ability of Schwann cells to adapt and… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS