Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

@article{Fukumoto2014FingolimodIB,
  title={Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment},
  author={Kazuya Fukumoto and Hiroyuki Mizoguchi and Hideyuki Takeuchi and Hiroshi Horiuchi and Akio Suzumura},
  journal={Behavioural Brain Research},
  year={2014},
  volume={268},
  pages={88-93}
}
Alzheimer's disease is a progressive neurodegenerative disorder. Amyloid β, a neurotoxic protein, causes disruption of hippocampal synaptic plasticity, and induces cognitive impairment in Alzheimer's disease. We previously revealed that fingolimod, a new oral immunosuppressant used to treat multiple sclerosis, ameliorates oligomeric amyloid β-induced neuronal damage via up-regulation of neuronal brain-derived neurotrophic factor (BDNF). Here, we showed that oral administration of fingolimod… CONTINUE READING
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