Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy.

  title={Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy.},
  author={Jens Ingwersen and Orhan Aktas and Patrick K{\"u}ry and Bernd C. Kieseier and Alexey N. Boyko and H C Hartung},
  journal={Clinical immunology},
  volume={142 1},
Fingolimod, also known as FTY720, has recently been approved by the regulatory authorities in the US, EU, Australia, Russia, among others, for the treatment of relapsing-remitting multiple sclerosis. Fingolimod therefore represents the first oral drug for the treatment of this autoimmune disease of the central nervous system. Fingolimod modulates sphingosine-1 phosphate receptors and has unique immunoregulatory properties. Mechanistic studies from animal models have shown that fingolimod… CONTINUE READING
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