Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway.

@article{Qin2017FingolimodPA,
  title={Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway.},
  author={Chuan Qin and Wen-Hui Fan and Qian Liu and Ke Shang and Madhuvika Murugan and Long-Jun Wu and Wei Eric Wang and Dai-Shi Tian},
  journal={Stroke},
  year={2017},
  volume={48 12},
  pages={
          3336-3346
        }
}
BACKGROUND AND PURPOSE White matter (WM) ischemic injury, a major neuropathological feature of cerebral small vessel diseases, is an important cause of vascular cognitive impairment in later life. The pathogenesis of demyelination after WM ischemic damage are often accompanied by microglial activation. Fingolimod (FTY720) was approved for the treatment of multiple sclerosis for its immunosuppression property. In this study, we evaluated the neuroprotective potential of FTY720 in a WM ischemia… CONTINUE READING
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