Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis

@article{Potenza2016FingolimodAD,
  title={Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis},
  author={Rosa Luisa Potenza and Roberta De Simone and Monica Armida and Valentina Mazziotti and Antonella P{\'e}zzola and Patrizia Popoli and Luisa Minghetti},
  journal={Neurotherapeutics},
  year={2016},
  volume={13},
  pages={918-927}
}
Fingolimod phosphate (FTY720), the first approved oral therapy for multiple sclerosis, primarily acts as an immunomodulator. Its concomitant effects in the central nervous system, however, indicate a potentially broader spectrum of activity in neurodegenerative diseases. In the present study, we investigated the possible effects of fingolimod in a mouse model of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by a strong neuroinflammatory component. Fingolimod (0… CONTINUE READING

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